Epub Nov Multicenter evaluation of IV acyclovir use prior to, during, and after a national shortage. Infect Dis Lond. Epub May Antimicrob Agents Chemother. Print May. Vol 91 4. August Endocrinol Diab Metab. Postgraduate Medicine. Endocrine Disorders. Emergency Contraception Algorithm and Guide for Clinicians. Nurs Womens Health. Doses, durations, and gender predict vancomycin-induced kidney injury in pre-clinical studies.
Int J Antimicrob Agents. Clin Ther. Print Feb. J Antimicrob Chemother. Crit Care Med. Print Jan. Print Aug. Open Forum Infect Dis. Diagn Microbiol Infect Dis. Epub Apr 2. Clin Infect Dis. Correction for Rhodes et al. Print Apr. Correlation between hospital-level antibiotic consumption and incident health care facility-onset Clostridium difficile infection.
Am J Infect Control. Population pharmacokinetics of cefepime of febrile neutropenia: implications for dose-dependent susceptibility and contemporary dosing regimens. Eight unexpected cases of vancomycin associated acute kidney injury with contemporary dosing.
J Infect Chemother. Epub Aug 3. Secular trends in nosocomial vancomycin-resistant enterococcal bloodstream infections among United States Veterans Affairs hospitals, fiscal years Infect Control Hosp Epidemiol. Journal of HIV and Retrovirus. Epub Dec NYS Pharmacist. McGraw-Hill, Antimicrobial Stewardship Principles and Practice. Boston: CAB International; Section II. Chapter 9. Prevention and Treatment of Herpes Zoster. Poster Presentation. New Orleans, LA. June Bidell, M, Cabral K.
October Bidell, M. Infectious Diseases Potpourri. Albany, NY. September Bidell, M, Watson A. Appropriate use of antibiotics: Upper respiratory infections. Continuing Medical Education. Webinar, Albany, NY. Rosa S, Briceland LL. Poster A Cardone KE, Seo S. Assessment of opioid-induced adverse event risk in patients on hemodialysis. Medication management strategies among patients with chronic kidney disease CKD.
Abstract June Presenter: Patel. Washington, D. Phoenix, AZ. San Diego, CA. November , Garrison GD. Time Management Strategies for Pharmacist Preceptors. Albany College of Pharmacy and Health Sciences. Michael P. Orlando, FL. December Late breaker abstract LB2. Presenter: Najafipour. Presenter: Britt. Abstract SUN Abstract SAT Title: Potential herb-chemotherapy or —radiation interactions in patients with cancer: A prospective study of the pharmacist and student pharmacist run herbal assessment service at the University of Vermont Cancer Center.
Michael Brodeur Brodeur MR. Medications and Falls. September 28, View details for PubMedID A fructo-oligosaccharide prebiotic is well-tolerated in adults undergoing allogeneic hematopoietic stem cell transplantation: a phase I dose-escalation trial. Transplantation and cellular therapy Andermann, T. Interventions that preserve the gut microbiome hold promise to improve HCT-associated morbidity and mortality.
We administered FOS starting at pretransplant conditioning and continuing for a total of 21 days. Community-level gut microbiota composition was significantly different on the day of transplant day 0 between patients receiving FOS compared to concurrent controls, however FOS-associated alterations of the gut microbiota were not sustained after transplant.
Although the impact of FOS was fleeting, transplantation itself impacted a substantial number of taxa over time. In our small pilot trial, no significant differences were observed in gut microbial metabolic pathways, stool SCFAs, or in peripheral Tregs although Tregs trended higher in those patients who received FOS. While alterations in the gut microbiota and peripheral immune cell composition in those receiving FOS are intriguing, additional studies are required to investigate the use of prebiotics in HCT recipients.
JCI insight Hirai, T. Immune molecular monitoring is under investigation to screen for rejection, though these techniques have suffered from low specificity and lack of spatial information. ImmunoPET utilizing antibodies conjugated to radioisotopes has the potential to improve early and accurate detection of graft rejection.
ImmunoPET is capable of noninvasively visualizing the dynamic distribution of cells expressing specific immune markers in the entire body over time. In this work, we identify and characterize OX40 as a surrogate biomarker for alloreactive T cells in organ transplant rejection and monitor its expression by utilizing immunoPET. In a dual murine heart transplant model that has both syngeneic and allogeneic hearts engrafted in bilateral ear pinna on the recipients, OX40 immunoPET clearly depicted alloreactive T cells in the allograft and draining lymph node that were not observed in their respective isograft counterparts.
OX40 immunoPET signals also reflected the subject's immunosuppression level with tacrolimus in this study. OX40 immunoPET is a promising approach that may bridge molecular monitoring and morphological assessment for improved transplant rejection diagnosis. View details for PubMedID Outcomes after delayed and second autologous stem cell transplant in patients with relapsed multiple myeloma.
Bone marrow transplantation Lemieux, C. Median PFS from salvage treatment and transplant were 28 and 19 months, respectively. Median OS from salvage treatment and transplant was 69 and 55 months. Ninety-five patients underwent delayed transplant at first relapse, median PFS and OS from start of therapy was 30 and 69 months, and median OS from diagnosis was months.
Blood Maas-Bauer, K. Experimental evidence in mice and observational studies in humans indicate that iNKT cells have antitumor potential as well as the ability to suppress acute and chronic Graft-versus-Host-Disease GvHD. Whether distinct iNKT sublineages also differ in their antitumor effect and their ability to suppress GvHD is currently unknown.
In this work, we generated highly purified murine iNKT-sublineages, characterized their transcriptomic and epigenomic landscape, and assessed specific functions. Conversely, we show that iNKT1 cells display the highest antitumor activity against murine B-cell lymphoma cells both in vitro and in vivo. Thus, we demonstrate for the first time that iNKT sublineages have distinct and different functions, with iNKT1 cells having the highest antitumor activity and iNKT2 and iNKT17 cells having immune-regulatory properties.
These results have important implications for the translation of iNKT cell therapies to the clinic for cancer immunotherapy as well as for GvHD prevention and treatment. Transplantation and cellular therapy Johnsrud, A. Fewer patients required PXF with chemo-mobilization Median cost of mobilization was Differences in time to engraftment were not clinically significant.
Given similar rates mobilization success, engraftment time, and less toxicity and lower costs compared to chemo-mobilization, G-CSF with on-demand PXF may be preferable in myeloma patients with adequate disease control and limited lenalidomide exposure. The Journal of clinical investigation Hirai, T. However, it is technically challenging to expand Tregs ex vivo for the purpose of infusing large numbers of cells in the clinic.
Here, we introduced this orthogonal IL-2R into Tregs. Our data indicate that selective target cell stimulation enabled by the engineered orthogonal cytokine receptor improves Treg potential for the induction of organ transplantation tolerance. However, collecting and storing backup stem cells in all patients requires significant resources and cost, and the rates of backup stem cell utilization are not well studied.
This timeframe was selected to allow for adequate follow-up. A total of patients were included. The median age was 58 years range, After a median follow-up of 6 years, the median progression-free survival PFS of the cohort was 3 years. A median of 5. Of the patients, 6.
Rates of backup stem cell use among patients aged View details for PubMedID Immune reconstitution and infectious complications following axicabtagene ciloleucel therapy for large B-cell lymphoma. Blood advances Baird, J. We evaluated the long-term course of hematologic recovery, immune reconstitution, and infectious complications in 41 patients with LBCL treated with axicabtagene ciloleucel axi-cel at a single center.
Overall, Blood advances Johnsrud, A. In the axi-cel subgroup, these occurred in Bleeding occurred between days median On univariate analysis, patients with bleeding were older median 72 vs. Blood advances Hirai, T.
However, a paucity of Tregs in the peripheral blood makes it difficult to acquire sufficient numbers of cells and hampers further clinical application. The combination of iNKT cell activation and Treg adoptive therapy may make Treg therapy more feasible and safer by enhancing the efficacy and reducing the number of Tregs required.
Non-invasive molecular imaging of CAR T cells by positron emission tomography PET is a promising approach with the ability to provide spatial, temporal and functional information. Reported strategies rely on the incorporation of reporter transgenes or ex vivo biolabeling, significantly limiting the application of CAR T cell molecular imaging.
The optimal treatment approach, including whether to pursue an autologous autoSCT or allogeneic alloSCT transplant is not clear as there is lack of clinical trial based evidence. Median age of the cohort was 58 years. The median OS from diagnosis was 27 vs. In conclusion, alloSCT was not observed to offer any significant survival advantage over autoSCT in PCL, which is comparable to other recent reports and relapse remains the primary cause of death.
Cancer research Alam, I. Non-invasive strategies detecting T cell activation would allow for early diagnosis and possibly more effective management of HCT recipients. Positron emission tomography PET imaging is a sensitive and clinically relevant modality ideal for GvHD diagnosis and there is a strong rationale for the use of PET tracers that can monitor T cell activation and expansion with high specificity. The tumor necrosis factor TNF receptor superfamily member OX40 CD is a cell surface marker that is highly specific for activated T cells, is upregulated during GvHD, and mediates disease pathogenesis.
We recently reported the development of an antibody-based activated T cell imaging agent targeting OX This approach enabled visualization of T cell activation at early stages of disease, prior to overt clinical symptoms with high sensitivity and specificity. JCI insight Marschner, D. However, immune-related adverse events irAEs occur frequently and can lead to ICI treatment termination. MicroRNAa miRa has regulatory functions in immune cells. We observed that mice lacking miRa developed significantly more severe irAEs compared to wildtype mice in several irAE target organs in two different murine models.
Therapeutic administration of a miRa mimic reduced irAE severity. We found that the SNP rs leading to reduced miRa expression was associated with an increased risk to develop severe irAEs, reduced progression-free survival and increased neutrophil counts both at baseline and during ICI therapy. In conclusion, we characterized miRa as a novel molecular target to prevent ICI mediated autoimmune dysregulation. Blood Erkers, T. Studies in mice have shown that these cells are heterogenous and capable of enacting diverse functions, and the composition of iNKT subsets can alter disease outcomes.
In contrast, far less is known about how heterogeneity in human iNKTs relates to disease. To address this, we use a high-dimensional, data-driven approach to devise a framework to parse human iNKT heterogeneity. Our data revealed novel and previously described iNKT phenotypes with distinct functions.
These populations, respectively, correlate with acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation and with new onset type 1 diabetes. Our study identifies human iNKT phenotypes associated with human disease that could aid in the development of biomarkers or therapeutics targeting iNKTs. The Journal of experimental medicine Frank, M. Subsequently, vaccine-primed lymphocytes were collected and reinfused after a standard autologous stem cell transplantation ASCT.
Vaccination with CpG-stimulated autologous tumor cells followed by the adoptive transfer of vaccine-primed lymphocytes after ASCT is feasible and safe.
Jessica Farrell received the Ernest J.
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| What does the point spread mean in sports betting | Epub Aug 3. Cancer research Alam, I. JCI insight Marschner, D. Oct ImmunoPET utilizing antibodies conjugated to radioisotopes has the potential to improve early and accurate detection of graft rejection. |
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Our ability to listen can get drowned out by focusing on too many metrics or trying to replicate the training of other runners. The more in tune you become with your body throughout your training, the more likely you are to catch small niggles before they become serious injuries. Kate Galliett is a movement specialist and coach who has worked with a wide variety of athletes to help them become unbreakable.
Kate Galliett on Becoming Unbreakable After getting her degree in Exercise Science, Kate Galliett earned multiple certifications as a personal trainer and in functional movement and mobility. She is an accomplished outdoorswoman who hikes, rock climbs, hunts and skis. Minus Related Pages For the past 30 years, the CDC Injury Center has been a leader in protecting Americans from injury and violence so that individuals, families, and communities can be safe, healthy, and thriving. Why Prevention Matters Experiencing injury or violence can have a lifelong impact.
People can suffer short-term effects, such as missing work or school, and long-term effects, such as chronic illness or death. Injury and violence cost society hundreds of billions of dollars in medical care and lost productivity each year. The Injury Center focuses on improving lives by stopping injuries and violence before they happen—also known as primary prevention.
When we act early, we can prevent the use and misuse of drugs, like opioids, that can lead to substance use disorders and overdose. Community violence takes lives and leaves a legacy of trauma. Young people are disproportionately impacted by violence in their communities, including firearm injuries and deaths— over half of US homicides in occurred among those ages 15 to Preventing community violence will lessen the physical, emotional, and financial pain that impacts individuals, their families, and communities.
What the Injury Center Does The Injury Center has been at the forefront of injury and violence prevention, using surveillance, research, programs, and partnerships to: build national data systems to track trends in violent deaths and overdose , research critical issues including ACEs and suicide, support health departments, research institutions, community-based organizations, and American Indian and Alaska Native Communities.
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